Gene expression deconvolution in clinical samples
نویسندگان
چکیده
منابع مشابه
Statistical expression deconvolution from mixed tissue samples
MOTIVATION Global expression patterns within cells are used for purposes ranging from the identification of disease biomarkers to basic understanding of cellular processes. Unfortunately, tissue samples used in cancer studies are usually composed of multiple cell types and the non-cancerous portions can significantly affect expression profiles. This severely limits the conclusions that can be m...
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This vignette motivates and describes the functionalities of the CellMix package, an R package for performing gene expression deconvolution analysis. The package defines a general framework to apply, develop and test gene expression deconvolution methods. It incorporates, generalises and extends the set of tools we implemented when developing a semi-supervised approach to this problem, and incl...
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ژورنال
عنوان ژورنال: Genome Medicine
سال: 2010
ISSN: 1756-994X
DOI: 10.1186/gm214